Increased seroreactivity to HERV-K10 peptides in patients with HTLV myelopathy
نویسندگان
چکیده
منابع مشابه
High prevalence of antibodies against HERV-K10 in patients with testicular cancer but not with AIDS.
Human endogenous retrovirus K10 (HERV-K10) env and gag expression has been detected in placenta, embryonic tissue, and cell lines. By transfection, these sequences have been expressed in insect cells and developed into serological assays, revealing HERV-K10 antibodies in patients with testicular cancer. Patients with AIDS are at an increased risk for testicular cancer and frequently reactivate ...
متن کاملHTLV-1 -associated Myelopathy
Chronic progressive spastic paraparesis occurring in tropical areas and southwest Japan is frequently associated with high antibody titers to HTLV-1 in serum and cerebrospinal fluid.12 We recently reported that T-lymphocyte alveolitis occurred in patients with HTLV-1-associated myelopathy (HAM).3 The presence of such pulmonary lesions were also described by Vernant and associates in patients wi...
متن کاملIncreased seroreactivity to proinsulin and homologous mycobacterial peptides in latent autoimmune diabetes in adults
Latent Autoimmune Diabetes in Adults (LADA) is a slowly progressing form of immune-mediated diabetes that combines phenotypical features of type 2 diabetes (T2D) with the presence of islet cell antigens detected in type 1 diabetes (T1D). Heterogeneous clinical picture have led to the classification of patients based on the levels of antibodies against glutamic acid decarboxylase 65 (GADA) that ...
متن کاملPain in tropical spastic paraparesis/HTLV-I associated myelopathy patients.
OBJECTIVE Tropical Spastic Paraparesis/HTLV-I Associated Myelopathy (TSP/HAM) is a chronic myelopathy, and pain has been mentioned as a frequent sensory symptom in this condition. The authors aimed at analyzing this symptom in a TSP/HAM patients series. METHOD For this, 46 patients were analyzed considering demographic and clinical characteristics and complaint of pain as to verbal descriptio...
متن کاملPulmonary involvement in patients with HTLV-I-associated myelopathy: increased soluble IL-2 receptors in bronchoalveolar lavage fluid.
A chronic spastic myelopathy associated with HTLV-I infection (HTLV-I-associated myelopathy: HAM) shows subclinical pulmonary involvement with bronchoalveolar T lymphocytosis. In the present study, we investigated 18 patients with HAM: five HTLV-I carriers without myelopathy and 13 normal control subjects seronegative for HTLV-I to determine if soluble IL-2 receptors (IL-2R), a marker of lympho...
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ژورنال
عنوان ژورنال: Virology Journal
سال: 2013
ISSN: 1743-422X
DOI: 10.1186/1743-422x-10-360